In Cheng et al. study, the sensitivity for OPMD detection based on ZNF582 and PAX1 gene methylation was reported for different grades of oral dysplasia, including hyperplasia (27% and 12%), mild dysplasia (68% and 32%), and moderate dysplasia (87% and 56%), respectively. The gene discussed is ZNF582; the disease is oculopharyngeal muscular dystrophy.