Regarding the potential of salivary DNA methylation markers for detecting OPMDs, Cheng et al. evaluated the sensitivity of methylated ZNF582 and PAX1 for detecting OPMDs with different grades of dysplasia, including hyperplasia (27% and 27%), mild dysplasia (36% and 24%), moderate dysplasia (62% and 54%), and severe dysplasia (67% and 50%), respectively. Here, ZNF582 is linked to dysplasia.