These effects are mediated through the coreceptors NRP1 and NRP2, since the blockade of NRP1 and NRP2 in MCF10DCIS_SEMA3F cells indicates that secreted SEMA3F, which acts via NRP1 and/or NRP2 but not through the collateral changes that result in its overexpression, is the main factor responsible for the effects detected in cancer cells. The gene discussed is SEMA3F; the disease is cancer.