Obviously, additional efforts must be devoted to clarifying the role of SEMA3F as an invasiveness cue in myoepithelial cells, but our results, as well as those of others [73, 74], reinforce the view that SEMA3F is produced by epithelial cancer cells prior to its progression to IDC and that myoepithelial cells are affected by local SEMA3F production at this precise temporal step in BC. This evidence concerns the gene SEMA3F and breast cancer.