APOE and obesity due to melanocortin 4 receptor deficiency: Among Egyptian populations, APOE genotyping has been linked to coronary artery disease (CAD) [16, 17], coronary heart disease (CHD) [18], type 2 diabetes mellitus (T2DM) with cardiovascular disease (CVD) [19], T2DM with nephropathy (T2DMN) [20], T2DM with obesity [13], and obesity [21].