There is evidence that APOE 2 allele carriers have higher APOE plasma levels, lower LDL cholesterol (LDL-C) plasma levels, and a reduced risk of coronary artery disease (CAD), while APOE4 allele carriers have lower APOE plasma levels, higher total cholesterol (TC), LDL cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C) plasma levels, and a higher risk of CAD when compared to APOE3 homozygotes [11]. Here, APOE is linked to coronary artery disorder.