The analysis of genetic mutations in Asian, European, and American populations in the context of VHL syndrome has provided a heterogeneity of VHL-associated mutations, specifically MSs, PTMs, L/C DELs, and their association with different VHL subtypes, which is similar to the study of Dollfus et al. [36] and Fagundes et al. [37]. The gene discussed is VHL; the disease is von Hippel-Lindau disease.