Bispecific antibodies (bsAbs) binding the CD3 T-cell receptor (TCR) subunit with one arm and a tumor associated antigen (TAA) with the other arm can recruit T-cells to tumor cells and trigger formation of an immune synapse with high similarity to that formed by natural TCR-major histocompatibility (MHC)/TAA interactions14. The gene discussed is HLA-C; the disease is neoplasm.