Furthermore, SARS-CoV-2 infection also led to the downregulation of Dicer, XPO5, SRSF3, and hnRNPA3 in mouse lung tissues (Fig. 7j), and overexpression of Dicer, XPO5, SRSF3, and hnRNPA3 in mouse lung tissues partially alleviated SARS-CoV-2-induced pneumonia (Fig. 7k and Supplementary Fig. 7h). Here, XPO5 is linked to susceptibility to pneumonia measurement.