Furthermore, SARS-CoV-2 infection also led to the downregulation of Dicer, XPO5, SRSF3, and hnRNPA3 in mouse lung tissues (Fig. 7j), and overexpression of Dicer, XPO5, SRSF3, and hnRNPA3 in mouse lung tissues partially alleviated SARS-CoV-2-induced pneumonia (Fig. 7k and Supplementary Fig. 7h). This evidence concerns the gene DICER1 and susceptibility to pneumonia measurement.