Furthermore, Dicer, XPO5, SRSF3, and hnRNPA3 knockdown exaggerated the N protein-induced DNA damage, apoptosis, cytosolic DNA accumulation, upregulation of IFNβ, IL-6, and NKG2D ligands, and pneumonia (Fig. 8f, g and Supplementary Fig. 8d–f). This evidence concerns the gene XPO5 and pneumonia.