In contrast, while sharing expression of multiple genes (e.g. col5a2, col12a1a, tnmd, ogna, postnb) with the periosteum cluster, MSM differs from OM and periosteum clusters by expression of several BMP antagonists (grem1a, nog2, nog3, bambia, fstl3), the Tgfb antagonist tgfbi, and members of the Angiopoeitin-like (Angptl) family (angptl1a, angptl1b, angptl2b, angptl5) that have been implicated in regulation of blood vessel development18,32 (Fig. 5A; Supplementary Fig. 8A). The gene discussed is ANGPTL5; the disease is ocular melanoma.