According to Prior et al., five frequent mutations account for 70% of all Ras-mutant proteins (G12D, G12V, G12C, G13D, and Q61R).489,490 K-Ras G12C mutation was identified in multiple CRC and lung cancer samples491–493 and K-Ras G12D mutation in pancreatic adenocarcinoma492 and K-Ras G12D mutation in pancreatic adenocarcinoma.494–497. This evidence concerns the gene KRAS and colorectal carcinoma.