VEGFR-2 high expression and single nucleotide polymorphisms rs1870377 A>T and rs7692791 were correlated with GC prognosis and poor survival.157,158 In the case of CRC, VEGFR-2 1192C/T and −604T/C single nucleotide polymorphisms are associated with microvessel density in tumor tissue.159 Other VEGFR-2 alterations might be correlated with Alzheimer’s disease based on a study performed on plasma samples obtained from mild cognitive impairment and Alzheimer’s disease patients.160. This evidence concerns the gene KDR and early-onset autosomal dominant Alzheimer disease.