ALK and cancer: It was observed that in the absence of LTK and ALK, neuronal migration, neural progenitor populations and cortical layers patterning were disrupted, thus some researchers suggest that the use of ALT/LTK inhibitors in cancer patients should be carefully monitored to avoid brain dysfunctions.211 Moreover, the mammalian RTK ALK was first described as the product of the t(2;5) chromosomal translocation found in non-Hodgkin’s lymphoma.212,213