ALK/LTK signaling pathway is responsible for the modulation of cell proliferation, invasion, migration, angiogenesis and apoptosis inhibition, via PI3K/Akt/mTOR, JAK/STAT/VEGF, Ras/Raf/MAPK, and PLCγ/PIP2/IP3 pathways in lymphomas, neuroblastoma and NSCLC.463,464. The gene discussed is ALK; the disease is non-small cell lung carcinoma.