The STAT3 gene is frequently mutated in hematopoietic neoplasms like T-cell large granular lymphocytic leukemia (T-LGL), PTCL, diffuse large B cell lymphomas (DLBCL), anaplastic large T-cell lymphoma (ALCL), and chronic NK lymphoproliferative disorders (NKTCL).599,602–607. This evidence concerns the gene STAT3 and mature T-cell and NK-cell non-Hodgkin lymphoma.