AXL and Kallmann syndrome: In a study, Salian-Mehta et al. have identified three missense AXL mutations (p.L50F, p.S202C, and p.Q361P) and one intronic variant (c.586-6C>T) in Kallman syndrome and norm osmic idiopathic hypogonadotropic hypogonadism subjects.355 In another study were described 53 AXL, 36 MER and 25 TYRO3 mutations identified on a cohort of 509 female patients diagnosed with endometrial adenocarcinoma.356,357 In all these cases the main majority were missense mutations.