ALK and non-small cell lung carcinoma: EMT has been demonstrated to be associated to EGFR- (afatinib) and ALK-inhibitor (crizotinib) resistance.673,706 EMT-caused resistance to sunitinib has been demonstrated too.707 Inactivation of the tumor suppressors RB1 or TP53 during RTK-inhibitor therapy may result in entire histological shifts, such as from NSCLC to a small-cell subtype.704