Furthermore, in both B- and T-ALL, several JAK1 mutations were described in different protein regions: I62V,611 K204M,611 R360W,611 S512L,611 L624_R629>W,609 A634D,611 S646F,609 L653F,611 V658F,609 R724H,611 L783F,611 R879C,611 R879H,611 R879S.611 Additionally, V623A and T468S mutations were identified in AML.612. This evidence concerns the gene JAK1 and acute lymphoblastic leukemia.