As in the case of RAS, RAF mutations are common in cancers like melanoma, CRC, ovary and thyroid malignancies.500–503 T1796A mutation in B-RAF gene change valine with glutamic acid in position 600 (V600E) and is the most frequent mutation.504,505 Three mutations were identified in C-RAF which induce MAPK cascade by activating C-RAF (G466E, G466V, and G596R).506. This evidence concerns the gene RAF1 and melanoma.