Even if the dysregulation is a result of mutant upstream proteins or due to overexpression of the receptors that trigger the pathway, the result is an uncontrolled cell growth.528–531ERK1/2 mutations can be responsible for the enhanced tumorigenic phenotype of the cells and lead to different cancers.532 ERK2 E322K mutation in present in cervical and head and neck cancer.533–535. The gene discussed is MAPK1; the disease is cancer.