STYK1 and acute leukemia: STYK1 is involved in metastasis and epithelial to mesenchymal transition and its overexpression is associated with poor prognosis in NSCLC patients.425 The ligands for these RTKs family are still unknown.424 Overexpression of STYK1 was also noticed in acute leukemia,426,427 hepatocellular carcinoma,428 ovarian cancer,429 NSCLC430 and castration resistant prostate cancer patients.431 At cellular level, overexpression of this receptor involves cell cycle late mitosis arrest and affects cell division.432