TAM receptors are overexpressed in different malignancies, such as leukemia, melanoma, gastric, colon, lung and BC, promoting cell survival.341–345 AXL biosynthesis is regulated by key transcription factors (AP1, Sp1/Sp3, YAP/TAZ/TEAD, HIF1α, MZF-1) and Toll-like receptor signaling in dendritic cells and macrophages, which increase AXL mRNA expression. This evidence concerns the gene AXL and melanoma.