MTOR and large cell neuroendocrine carcinoma: The mutations C1483Y and R2430M were detected in T cell leukemia, R460*, S2215Y and E1799K in endometrial carcinoma cells, with E1799K also detected in kidney cancer cells.566 The mTOR mutation L2209V was identified in a specimen of large cell neuroendocrine carcinoma, and it was showing the ability to transform fibroblasts into tumor-like cells.567 The H419R mTOR mutation was detected in thyroid carcinoma cells and G2359E in melanoma tumors.568