FGFR3 and lung cancer: FGFR gene fusions can appear due chromosomal rearrangements or translocations, increasing the receptor dimerization or dysregulating the expression of FGFR. Helsten et al, identified the FGFR2/FGFR3 and TAAC3 fusion as one with high frequency.96 In triple negative breast cancer (TNBC), FGFR2 fusion partners AFF3, CASP7, and CCDC6 aberrantly activate the gene, while in lung cancer other two fusions were detected (FGFR3-TACC3; FGFR2-CIT).