The activation of RTKs triggers multiple signaling pathways, including the Rac/MEKK1/MEKK/JNK pathway, Ras/Raf/MEK1/2/ERL/1/2 pathwayPI3K/Akt/NFKB pathway and JAK/STAT pathway.440,441 Multiple molecules were developed to target the downstream effectors of these pathways in order to inhibit tumor cells’ growth and proliferation (Fig. 5). Here, SOAT1 is linked to neoplasm.