HGF and cancer: Elevated levels of HGF in both tumor tissues and plasma have been observed in patients with various types of cancers, such as invasive breast carcinoma, glioma, and multiple myeloma.193–195 The information regarding mutational status of these receptors and the mechanism of action in different malignancies are detailed in Table 7, with specific details regarding the encoding genes and the oncogenic status of the mutations that were detected in each receptor.