LMTK2 gene expression is affected in the early stages of prostate cancer, this gene could be taken into consideration as a potential biomarker for clinical stratification of prostate cancer patients.416 Moreover, LMTK2 gene rs6465657 SNP was detected in the case of prostate cancer in some studies.416,417 The LMTK3 gene has been identified as overexpressed in bladder,418 breast419, and colorectal420 cancers. Here, LMTK3 is linked to Familial prostate cancer.