Chakraborty et al. detected several structural alterations in EphA3 (A749D, W790C, F152S), EphA7 (L749F), EphB1 (G685C) and in EphB4 (V748A), all mutations inducing changes in NSCLC samples.300 The mutations impact in NSCLC remains unclear and needs further functional analysis for each mutation. This evidence concerns the gene EPHB4 and non-small cell lung carcinoma.