ROR1 and neoplasm: EGFRs, VEGFRs, PDGFRs, FGFRs, ROR1, ROR2, and other RTKs accumulate a series of modifications which trigger their activation and lead to a metabolic reorganization in tumor cells thus increasing their tumorigenicity.58,59 RTKs overexpression was spotted in solid and hematological malignancies, contributing to the enhanced cell proliferation, differentiation, migration, and cell death regulation.60