Smiech et al., synthesized the information related to RAF mutations.507 BRAF D594 mutations were identified as follows: D594A in CRC, D594E in melanoma and multiple myeloma, D594G and D594N in NSCLC, multiple myeloma and CRC, and D594H in NSCLC.508–512. This evidence concerns the gene BRAF and plasma cell myeloma.