EGFR and non-small cell lung carcinoma: EGFR mutations are frequently discovered in NSCLC, according to Fu et al. the four generations of EGFR-TKIs are efficient if different mutation status of NSCLC cells.89 Tumors with single mutation (Ex19del/L858R; T790M and C797S) can be targeted by all four generations of EGFR-TKIs; Double mutant cells are sensitive to all EGFR-TKIs except 2nd generation while cell with triple mutant status are sensitive only to the 4th generation of EGFR-TKIs.