Roll and Reuther evaluated the ALK activating mutations in LTK, using a benign tumor model (pheochromocytoma—adrenal gland benign tumor) in mice.219 This study identified specific ALK mutations like F1147L and R1275Q, and the corresponding LTK mutations F568L and R669Q. The gene discussed is ALK; the disease is benign neoplasm of adrenal gland.