The AKT1 E17K mutation is responsible for leukemia development in mice models,553 moreover it can induce oncogenic transformation in normal breast epithelial cells (MCF10A).554,555 This mutation is present in different types of cancer, with different frequencies, such as BC, endometrial cancer, skin and bone cancer, thyroid and colon cancer.556–559. This evidence concerns the gene AKT1 and cancer.