Conversely, MEK compensatory resistance genes, such as IGFBP3,139,140 MAP2,141 and SERPINE1,142 were upregulated and contributed to resistance to anticancer therapy with EGFR TKI in the DTP cells.143 Noronha et al.144 observed the up-regulation of Growth Arrest-specific Protein 6 (GAS6) in residual cells of anti-EGFR treated lung cancer, leading to the subsequent formation of DTP cells. This evidence concerns the gene EGFR and lung carcinoma.