Moreover, the IGF-1R pathway and its associated Akt pathway, linked to KDM5A and H3K4 targets, are also modulated in DTP cells.186 Additionally, the activation of the transcription factor FOXA1 has been observed in EGFR mutant NSCLC treated with Osimertinib, resulting in the upregulated expression of IGF-1R and induction of the DTP cells.187. Here, IGF1R is linked to non-small cell lung carcinoma.