IL4 and Alzheimer disease: There are dozens of AD susceptibility loci characterized in diverse populations, which mediate functions such as response to interferon gamma (IFNγ), innate immunity, T lymphocyte functions, and epidermal barrier dysfunctions (Table 1).26, 29, 30 Similarly, the most relevant associations of signaling pathways analyzed by the Reactome database were those of the interleukins IL4/IL-13, IL-2 and IL-12.31