Also, the association of eczema herpeticum and serum IgE levels with methylation in the IL-4 and IL-13 genes.41, 42, 43 Furthermore, there are microRNAs that are up- or downregulated in the skin or serum of patients with AD, such as MiR-144, associated with early onset of the disease.31 This evidence concerns the gene IGHE and Alzheimer disease.