IL12RB1 and Alzheimer disease: Furthermore, the FLG has mutations associated with the earlier onset of the disease (as does NLRP10), while other SNPs in genes such as AFF1 and EHMT1 increase susceptibility to the later onset of AD.34, 35 A meta-analysis of candidate gene studies in Europeans and Asians confirmed the association between FLG variants and AD risk and further revealed new associated loci in Europeans, IL-18 and TGFB1, and in Asians, IL12RB1 and MIF. 36