Gzms play multi-faceted roles that involve novel activities that are still being assigned, such as the function of human GzmA in driving pyroptosis by cleaving Gasdermin B.44While it remains to be established exactly how GzmA functions in Salmonella infection, we have now established that GzmA protects against intestinal infection, and that Salmonella can co-opt GzmB-mediated apoptosis for its growth. The gene discussed is GZMA; the disease is digestive system infectious disorder.