These enrichments were attributable to skin cancer GWAS loci such as rs7705526, a variant located in an intron of TERT, and rs1805008, a missense variant of MC1R. In addition, a similar pervasive enrichment of meQTL effects was observed for GWAS loci of skin-related immune traits and diseases, with 11 of 13 considered phenotypes showing enrichment effects. Here, MC1R is linked to skin neoplasm.