CDK10 and keratinocyte carcinoma: Another example of a mediation effect related to skin disease involves CDK10 with rs1805008 (c.478C>T [GenBank: NM_002386.4] [p.Arg160Trp]), a missense variant in an exon of MC1R. MC1R variants, and rs1805008 in particular, have been identified as important risk variants for melanoma, keratinocyte carcinoma, and sunburn.29