Cis-CpGs identified in EWASs of these traits included a CpG in the gene body of ARRB2 (involved in the Hedgehog signaling pathway, which has been linked to SCC99) for high-risk cSCC, a CpG in the 3′ UTR of CSK (involved in Src kinase signaling, which has been linked to squamous cell carcinoma [SCC]100) for cSCC survival, a CpG in the gene body of RAP1GAP (which has been previously linked to human papillomavirus infection101) for non-genital cutaneous warts, and four CpGs near the TSS of PSORS1C1 (psoriasis susceptibility 1 candidate 1) for psoriasis. The gene discussed is RAP1GAP; the disease is skin squamous cell carcinoma.