We find that the rs1805008 risk allele for melanoma, keratinocyte cancer, and sunburn (C > T) is associated with reduced expression of CDK10 and also reduced DNA methylation of cg00001687 (posterior probability of colocalization = 0.96) located within one of the last introns of MC1R. Mediation analysis shows putative mediation via both SME or SEM pathways (Sobel p = 0.00017 and 0.00011, respectively), although SEM is more likely (26% mediation in the SEM model vs. The gene discussed is CDK10; the disease is melanoma.