Another example of a mediation effect related to skin disease involves CDK10 with rs1805008 (c.478C>T [GenBank: NM_002386.4] [p.Arg160Trp]), a missense variant in an exon of MC1R. MC1R variants, and rs1805008 in particular, have been identified as important risk variants for melanoma, keratinocyte carcinoma, and sunburn.29 The gene discussed is MC1R; the disease is melanoma.