CD274 and neoplasm: Bubble plots paraded the classical KEGG pathways, enriched by the DEGs, involved in tumor malignant progress, tumor immunity, tumor inflammatory response and gene mutation, such as NF-kappaβ signaling pathway, PD-L1 expression, and PD-1 checkpoint pathway, IL-17 signaling pathway, DNA replication related-pathway, etc., (Figure 4E).