Single-cell analysis also indicated the presence of innate immune cells including 4 tumor-associated macrophage (TAM) populations: lysosomal (CSTB, LYZ, and LIPA); inflammatory (IFI6, IFIT1, ISG15, CCL4); APC-like (CTSD, MS44A4A, MS4A6A); RNA splicing (MALAT1, SLC1A3, SLC38A2); type 2 conventional DCs (CLEC10A, FCER1A); plasmacytoid DCs (CLEC4C, IL3RA); monocytes (VACN, FCN1, S100A8); and neutrophils (LY6G6D, JMJD1C, CD117) (Figure 2D and Supplemental Table 4). Here, ISG15 is linked to neoplasm.