The observed improvements in waist-to-hip ratio, waist circumference, BMI, weight, fasting blood sugar (FBS), HbA1c, liver enzymes (ALT, GGT), lipid profile (LDL, triglycerides, total cholesterol), renal function markers (BUN, creatinine), Fatty Liver Index (FLI), and estimated Glomerular Filtration Rate (eGFR) underscore the comprehensive benefits of LV-HIIT as a non-pharmacological intervention for managing diabetes-related complications. This evidence concerns the gene GPT and diabetes mellitus.