LEP and obesity due to melanocortin 4 receptor deficiency: These homodimers can activate Janus kinases to activate transcription.6 The LEP gene is located at position 7q31.3 and consists of 3 introns and 3 exons spanning approximately 18 kb.7 The LEPR gene on chromosome 1p31 encodes a single transmembrane protein 1165 amino acids in length and is distributed in many tissue types.8 Several single nucleotide variants (SNVs) have been identified in the highly polymorphic LEP and LEPR genes that are potentially associated with the pathophysiology of obesity, diabetes, and related complications.