The relationship between the LEP rs7799039 and LEPR rs1137101 genotype distribution and demographic and clinical characteristics, such as sex, fasting blood glucose, hypertension, triglyceride, retinopathy, nephropathy, neuropathy, coronary heart disease, cerebrovascular accident, BMI, waist circumference, HbA1C, insulin, C-peptide, creatinine, blood urea nitrogen, uric acid, AST, ALT, LDL, HDL, total cholesterol, triglyceride, Hb, and spot urine protein/creatinine ratio, were also analyzed. The gene discussed is INS; the disease is Nephropathy.