The LEP rs7799039 variant in the promoter of the gene is hypothesized to affect transcription levels and LEP expression.20 The A allele of LEP rs7799039 was associated with twice as much leptin secretion from adipocytes as the G allele.21 As the GA genotype of LEP rs7799039 is associated with hyperglycemia and hypercholesterolemia, it is mostly associated with the development of MetS. This evidence concerns the gene LEP and familial hypercholesterolemia.