For example, Ace2S680D (phosphomimetic state) and Ace2S680L (phosphorylation-deficient state) mice both implicate AMPK in pulmonary hypertension, whereas Tbk1S511A (phosphorylation-deficient state) and Tbk1S511E (phosphomimetic state) mice show opposing effects on viral immunity. This evidence concerns the gene PRKAA1 and pulmonary arterial hypertension.