In HRD patients, epithelial cells remained as genome‐unstable cells, suggesting a potential high neoantigen load, which is correlated with increased immunogenicity.[38] In HRP patients, epithelial cells were distinctly characterized by high expression of HDAC1, SIRT2, TGFB1, and GSK3B, which are correlated with poor prognosis in HGSTOC, suggesting that these factors could be novel potential therapeutic targets. This evidence concerns the gene SIRT2 and hypoparathyroidism-retardation-dysmorphism syndrome.