Previous studies on NEU2 and NEU3 have primarily concentrated on their implications in cancers, intestinal and pulmonary disorders, as well as neurological conditions.[39, 40, 41] We and others have demonstrated the contribution of NEU1 in cardiovascular diseases and renal injury.[4, 42, 43] It is noteworthy that NEU4 and NEU1 exhibit similar functionality in the context of renal fibrosis, despite disparities in their protein sequences, subcellular localization, and enzymatic substrates. This evidence concerns the gene NEU2 and cardiovascular disorder.