Previous studies on NEU2 and NEU3 have primarily concentrated on their implications in cancers, intestinal and pulmonary disorders, as well as neurological conditions.[39, 40, 41] We and others have demonstrated the contribution of NEU1 in cardiovascular diseases and renal injury.[4, 42, 43] It is noteworthy that NEU4 and NEU1 exhibit similar functionality in the context of renal fibrosis, despite disparities in their protein sequences, subcellular localization, and enzymatic substrates. The gene discussed is NEU2; the disease is renal fibrosis.