TGF‐β is an anti‐inflammatory cytokine, and its reduction can lead to miscarriage due to disturbance of the immune tolerance environment and defects in placental development.[32] To our surprise, both engineered Exos with biocompatibilities (Figure S11, Supporting Information) mitigated abortion, with the treatment of GC‐Exo‐CD16Ab after LPS challenge demonstrating the most pronounced effect (Figure S12B,C, Supporting Information). Here, TGFB1 is linked to Miscarriage.