Similar crosstalk between T cells and microglia has been observed in studies on cerebral ischemia, where Th1/CD86+microglia crosstalk exacerbates immune responses after stroke, contributing to brain damage, whereas crosstalk between Th2 and CD163+microglia plays an anti‐inflammatory role, contributing to brain recovery.[25, 26] Furthermore, our findings indicated that the intervention of peripheral CD4+ T cells can affect the reaction of central microglia. Here, CD86 is linked to brain ischemia.