Notably, the proportion of CD4+ T cells and elevated T‐bet/GATA3 ratio showed a positive correlation with soluble neurofilament light chain (sNfL) levels, implying a potential link between the response of circulating CD4+ T cells and neuronal injury during TLE development and implicating these cells in the pathophysiology of epilepsy‐related neuronal damage. Here, CD4 is linked to epilepsy.