Blood‐brain barrier (BBB) integrity is compromised in epilepsy, including TLE, which potentially facilitates the infiltration of immune cells, notably CD4+ T cells, into the brain parenchyma.[4] Notably, CD4+ T cells have been implicated in epilepsy‐related peripheral inflammation in TLE patients and rodent models.[10, 11, 12] Inflammatory conditions elsewhere in the body can influence the CNS and potentially contribute to neuronal hyperexcitability. The gene discussed is CD4; the disease is epilepsy.