In the resected brain tissue of lithium chloride‐pilocarpine‐induced TLE rats in the chronic phase, we observed that the expression of CD32 and CD86 (markers of pro‐inflammatory microglia reactive to epilepsy) increased, and the expression of CD163 and CD200R (markers of anti‐inflammatory microglia reactive to epilepsy) decreased in the epileptogenic focus and distant brain regions (Figure 4A). This evidence concerns the gene CD86 and epilepsy.