Simultaneously, similar to our previous observations in germline KO mice, the loss of TMEM16F in myeloid cells led to exacerbated liver injury after infection, as evidenced by higher serum levels of AST and ALT, an increased level of the IL‐18 in the serum, and a substantial accumulation of lipids by staining of Oil Red O in liver samples (Figure 6E; Figure S7F–G, Supporting Information). Here, IL18 is linked to infection.