As a result, TMEM16F KO mice experienced significant liver damage and an intensified pro‐inflammatory response following Listeria infection, as evidenced by heightened alanine transaminase (ALT) and aspartate transaminase (AST) activities, along with increased levels of the inflammatory cytokine IL‐18 in the serum (Figure 4C–E). This evidence concerns the gene IL18 and listeriosis.