It has been hypothesized that Dyrk1a, a gene found in three copies in humans with DS and in Ts65Dn mice, significantly contributes to many DS phenotypes, including skeletal malformations (Arron et al., 2006; Duchon and Herault, 2016; Sloan et al., 2023). This evidence concerns the gene DYRK1A and Dravet syndrome.