CFHR1 and systemic lupus erythematosus: Table 4 shows the association of FHR1-deficiency with clinical manifestations of SLE included in the 1982 ACR criteria. No specific disease manifestation was associated with the deficiency, except for hematologic disorder. However, our data analysis showed that patients with FHR1-deficiency were diagnosed with SLE at a significantly younger age compared to those without deficiency (P=0.048; Figure 4).