CFHR1 and systemic lupus erythematosus: However, SLE patients showed a significantly higher prevalence of undetectable FHR1 compared to all healthy controls (35/378 SLE patients versus 6/168 healthy controls; p= 0.0214, OR=2.751, 95% CI = 1.115 – 8.164), with a consistent trend across all ethnic subgroups.