Through comparative profiling of peptides presented in OPSCC tissue and healthy tonsils (HT), we found that many of the top class I and II TAP source proteins, such as CTNNB1, TP53, KDMB5, EGFR, and COL6A1, are closely linked to oncogenic pathways previously identified in HNSCC or other cancer entities (19, 20, 58–60). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.