Moreover, a whole-genome sequencing in 3 large rosacea families and whole exome sequencing in 49 additional validation families from Han population which revealed rare, single deleterious variants of LRRC4, SH3PXD2A, and SLC26A8, which are genes for neural synaptic processes and cell adhesion, in large families with rosacea. Here, SLC26A8 is linked to rosacea.