CD8A and neoplasm: Generally, in the tumor immune process, nanovaccines load tumor-specific antigens (L) through a nano-delivery system, initiate the tumor antigen in lymph nodes (D), are internalized by dendritic cells (DCs) (I), stimulate DC maturation (M), and present peptide-MHC class I complexes to CD8+ T lymphocytes (P), a process referred to as the LDIMP cascade (54).