VCAN and inflammatory bowel disease: It is notable that our research extended the analysis of the IBD-nutrition-OP causal pathway, identifying lead SNPs (rs4920608, rs115912456, rs10875906, rs3184504, rs112635299, and rs56094641) and genes associated with potentially deleterious mutations (MFAP2, ATP13A2, SERPINA1, FTO, and VCAN).