It is notable that our research extended the analysis of the IBD-nutrition-OP causal pathway, identifying lead SNPs (rs4920608, rs115912456, rs10875906, rs3184504, rs112635299, and rs56094641) and genes associated with potentially deleterious mutations (MFAP2, ATP13A2, SERPINA1, FTO, and VCAN). Here, MFAP2 is linked to inflammatory bowel disease.