CD127, the IL-7 receptor α chain, and CD26, an extracellular peptidase expressed at high levels by memory T cells (53) and able to orchestrate the migratory response of T cells during inflammation (54) appear more expressed in HD-specific than in patients-specific metaclusters, confirming the highly differentiated effector phenotype of the latter. The gene discussed is DPP4; the disease is Huntington disease.