These variations suggested a trend towards a lower frequency of “classical” (CD14brightCD16-) monocytes in patients with severe COVID-19 (not significant; Figure 1A), confirmed by the accumulation of “non-classical” – also called inflammatory – (CD14+CD16bright) monocytes (35) in the same group (p<0.05; Figure 1C). The gene discussed is CD14; the disease is COVID-19.