EZH2 and Merkel cell skin cancer: Thus far, there is conflicting data on the potential efficacy and mechanism of EZH2 inhibitors in MCC, with 2 reports finding that inhibition of the EZH2 methyltransferase activity had cytotoxic effects on VP-MCC cells and/or xenografts (208, 210), whereas another study found that protein degraders of EZH2 impaired VP-MCC cell line viability independently of the methyltransferase function (211).