IDH2 and Merkel cell skin cancer: Other hotspot activating mutations reported in MCC include TERT promoter, KNSTRN, RAC1, HRAS, KRAS, NRAS, AKT1, CTNNB1, IDH1, IDH2 and EZH2, among others (2, 42, 43, 45, 86, 102, 157, 162, 163).