Other hotspot activating mutations reported in MCC include TERT promoter, KNSTRN, RAC1, HRAS, KRAS, NRAS, AKT1, CTNNB1, IDH1, IDH2 and EZH2, among others (2, 42, 43, 45, 86, 102, 157, 162, 163). This evidence concerns the gene EZH2 and Merkel cell skin cancer.