EZH2 is a histone methyltransferase that has been shown to be overexpressed in MCC and can play a role in tumorigenesis by epigenetic gene silencing.However, the loss of H3K27Me3 in VN-MCC raises questions regarding the role of EZH2, and thus the potential efficacy of EZH2 inhibitors, in that subset of MCC. This evidence concerns the gene EZH2 and Merkel cell skin cancer.