PRDM9 and Merkel cell skin cancer: EZH2 is a histone methyltransferase that has been shown to be overexpressed in MCC and can play a role in tumorigenesis by epigenetic gene silencing.However, the loss of H3K27Me3 in VN-MCC raises questions regarding the role of EZH2, and thus the potential efficacy of EZH2 inhibitors, in that subset of MCC.