AKT1 and hepatocellular carcinoma: Furthermore, LOXL1-AS1 acts as a ceRNA to elevate inositol 1, 4, 5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2) level through targeting miR-1224–5p and exhibit the malignant phenotypes of HCC via activating AKT pathway, thereby playing an oncogenic role in HCC (34).