The new frontier in the field will be the assessment of the impact of somatic polymorphism on leukemia risk; we previously identified a significant risk locus for leukemia at 11q13.2 (rs4930561; KMT5B) (24), and there is increasing evidence of germline predisposition to clonal hematopoiesis (25, 26). The gene discussed is KMT5B; the disease is leukemia.