BRAF and metastatic malignant neoplasm in the lymph nodes: Although the current risk stratification for thyroid cancer does not include intraglandular dissemination as a factor, and research on the correlation between intraglandular spread and I131 is also lacking, previous studies have shown a close association between intraglandular dissemination and lymph node metastasis, extrathyroidal invasion, and BRAF V600E mutation (5, 64).