SHANK1 and Sepsis: It was noted that several genes with DRE were previously reported or implicated to play a role in sepsis or SAE, such as superoxide dismutase 2 (SOD2), Miat, peptidylarginine deiminase 2 (Padi2), Shank1, transcription factor 4 (Tcf4) and kinesin family member 3 (Kif3c) (Supplementary Table 1).