By analysing the hippocampal RNA-seq data set of the study, our results indicated that fullerenol pre-treatment showed effects on sepsis-associated RNA editing by partially rescuing sepsis-associated RNA editing alterations, such as the p.M620V missense editing in Grik2, a gene under-edited in bipolar disorder.62 Such findings implicate the potential therapeutic potential of RNA editing in SAE and warrant further investigation of the effects of more antidepressants on sepsis-associated RNA editing in future studies. Here, GRIK2 is linked to bipolar disorder.