Studies have shown that Meg3 can relieve intestinal injury caused by LPS-induced sepsis by regulating miR-129-5p and surfactant protein D.58 However, Meg3 was also reported as a biomarker for predicting increased systemic inflammation, risk, disease severity and poor prognosis of sepsis.59,60 Importantly, our previous study suggested that altered Meg3 and Snhg11 RNA editing in the dorsal striatum could be associated with repeated winning and losing experiences in chronic social conflicts.41 In the current study, both genes were differentially edited during sepsis. The gene discussed is MEG3; the disease is Sepsis.