SOD2 and Sepsis: SOD2 is a mitochondrial enzyme that catalyzes the conversion of superoxide radicals to hydrogen peroxide and oxygen and thereby plays a crucial protective role against oxidative damage and inflammation in sepsis.32 SOD2 regulates lung oxidative damage and coagulation during sepsis, and enhancing its activity or delivery could be a potential therapeutic strategy.32,33Padi2 encodes an enzyme that converts arginine residues to citrulline residues in proteins and plays a potential role in developing sepsis by modulating the inflammatory response.