One example was that EVs derived from IFN-γ-stimulated iMSCs (IFN-γ-iMSC-EVs) inhibited Th2-induced immune responses, suppressed inflammation and pruritus concerning the reduced activity of the NF-κB and IL-31R-STAT signaling pathway, and facilitated skin barrier restoration which might be involved in the increasement of expression of skin barrier integrity-related genes and production of lipid synthesis-related proteins in atopic dermatitis (AD) (Kim J. et al., 2022). Here, IFNG is linked to Pruritus.