BRCA1 and breast carcinoma: Besides, to explore how the absence or mutation of the breast cancer susceptibility gene 1 (BRCA1) influences tumor progression, researchers employed reprogramming techniques and formulated a model of breast cancer featuring BRCA1 deletion, termed BRCA1+/−iMSCs, revealing that, in contrast to BRCA1+/+ iMSCs, BRCA1+/−iMSCs prompted angiogenesis, culminating in tumor growth and metastasis (Portier et al., 2021).