CDKN2B-AS1 and coronary artery disorder: Further research suggests that ANRIL may modulate vascular smooth muscle cell proliferation, cell adhesion, and apoptosis through multiple mechanisms including cis, trans, and Polycomb complex protein binding, possibly contributing to the risk of coronary artery disease (Kotake et al., 2011; Pasmant et al., 2011; Congrains et al., 2012a; Congrains et al., 2012b; Motterle et al., 2012; Tsai et al., 2012; Ahmed et al., 2013; Bochenek et al., 2013; Holdt et al., 2013; Johnson et al., 2013; Chen et al., 2014).