ANRIL is located in the 9p21 genomic region, which also encodes cell cycle regulatory factors such as p14 (ARF), p15 (INK4b), and p16 (INK4a), potentially increasing the risk for clinical/subclinical coronary artery disease and aortic disease (Holdt et al., 2010). This evidence concerns the gene CDKN2A and coronary artery disorder.