The findings from this study, combined with those from other research focusing on specific mutations (c.560delT (p.Val187Alafs∗29) (19) and c.676G > C) in MC2R, indicate that these patients with these mutations commonly exhibit clinical symptoms such as hyperpigmentation, frequent infections, lack of growth, hypoglycemic attacks, and seizures, which can potentially progress to coma or result in fatality. This evidence concerns the gene MC2R and infection.