Future work could explore, for example, the potential effects on the non-conducting role of Kv2.1 in integrin-K+ channel complexes, considered important for normal neuronal migration, proliferation, survival and death (Forzisi and Sesti, 2022) and implicated in the abnormal neocortical development observed in KCNB1 developmental epileptic encephalopathy (Bortolami et al., 2023). Here, KCNB1 is linked to developmental and epileptic encephalopathy.