HNRNPDL and autosomal dominant limb-girdle muscular dystrophy type 1G: This panel revealed a heterozygous VUS in HNRNPDL c.259 C>T/p.Arg87Cys causative of autosomal dominant limb-girdle muscular dystrophy type 1G (LGMD1G), a phenotype inconsistent with patient A’s presentation with a gnomAD frequency of 0.007%, in silico ambiguity as to the deleterious nature of this variant on protein structure/function, and no reports of this variant being causative of LGMD1G in the literature.