The levels of vitamin B12, folate, antinuclear antibody (ANA), Scl-70 antibody, SSA 52 (Ro) (ENA) antibody, SSA 60 (Ro) (ENA) antibody, SSB (La) (ENA) antibody, alpha-fetoprotein (AFP), tumor markers CA 125 and CA 19-9 were also within normal limits. This evidence concerns the gene AFP and neoplasm.