Although the consumption of the HSD did not cause renal hypertrophy per se (Figures 1E, F), C21 decreased the left kidney weight (p < 0.05, HSD + C21 vs HSD), which was reversed by the MasR antagonist A779 (p = ns, HSD + A779 + C21 vs C21). Here, CHST3 is linked to cardiac hypertrophy.