Of the 3 identified signals, one SD increase in genetically predicted NUDT13 methylation at cg04833713 was associated with a decreased risk of AF (OR 0.95, 95% confidence interval [CI] 0.93-0.97), whereas one SD increase in genetically predicted ECI1 methylation at cg27608139 and one SD increase in genetically predicted RHOT2 methylation at cg27336518 were associated with increased risk of AF (OR 1.05, 95% CI 1.03–1.08; OR 1.07, 95% CI 1.03–1.10, respectively). Here, ECI1 is linked to atrial fibrillation.