Genetically predicted expression levels of PCCB and STX17 were associated with increases in AF risk in atrial appendage (OR 1.12, 95% CI 1.01-1.24, p = 0.025; OR 1.13, 95% CI 1.04-1.23, p = 0.006, respectively). Here, PCCB is linked to atrial fibrillation.