Strong associations with increased risk of AF were identified with increased expression level of 4 mitochondria-related genes, including PCCB (OR 1.09, 95% CI 1.05–1.12; PPH4 = 0.95), COX18 (OR 1.83, 95% CI 1.29–2.60; PPH4 = 0.83), SLC25A15 (OR 1.34, 95% CI 1.14-1.58; PPH4 = 0.85), and STX17 (OR 1.16, 95% CI 1.08–1.24; PPH4 = 0.76). Here, COX18 is linked to atrial fibrillation.