Additionally, aspirin mediates the formation of the antiapoptotic protein Bcl-2 and FKB-2 complex through non-COX-dependent signaling pathways, induces the nuclear translocation and phosphorylation of Bcl-2, and mediates the overexpression of the pro-apoptotic protein Bax gene, thereby promoting the apoptosis of tumor cells (Choi et al., 2013). This evidence concerns the gene BCL2 and neoplasm.