Numerous studies have reported that the neurotransmitters 5-HT and NE play a significant role in the onset and progression of depression, and that the Anxa1, Serpinf1, Arrb1, Cplx2, Nrg1, and Psen1 genes regulate the levels of the neurotransmitters 5-HT and NE, thereby affecting behavioral indicators in rats and mice (Szapacs et al., 2004; Glynn et al., 2010; Levchenko et al., 2020; Peritore et al., 2020; Martin-Sanchez et al., 2021; Bai et al., 2022; Chen et al., 2022). This evidence concerns the gene ARRB1 and major depressive disorder.