By analyzing the correlation between genes, neurotransmitters, and behavior, we speculated that SNS can upregulate Anxa1 and downregulate Nrg1 and Psen1, thereby altering the release of the neurotransmitter NE, and ultimately leading to an improvement in depressive-like behavior while accompanying learning and memory impairment in the CUMS-depression model. This evidence concerns the gene ANXA1 and major depressive disorder.