Given that mesenchymal-like features in glioblastoma cells can be significantly enhanced by various tumor-related processes, such as hypoxia, necrosis and inflammation (Kim et al., 2021), we decided to investigate the effect of soloxolone amides on GMT induced by transforming growth factor beta (TGF-β), a known GMT activator produced by microglia, tumor-associated macrophages, and tumor cells themselves in the glioblastoma microenvironment (Golán-Cancela and Caja, 2024). Here, TGFB1 is linked to neoplasm.