LDHA and neoplasm: Given the observed decrease in stem cell-related ALDH activity in U87 cells treated with 7 at 50 nM (Figure 4F), we speculate that 7 at low concentrations may induce the transition of GSCs into differentiated tumor cells with greater proliferative activity by suppressing their stemness, but this effect may be counteracted by the cytotoxicity of 7 at higher concentrations (Lan et al., 2017).