The results show that compound 7 has a higher cytotoxic potential and pro-apoptotic activity against glioblastoma cells in vitro than TMZ (Figures 5A, E, G), whereas in the murine U87 xenograft model, these compounds exhibited comparable levels of tumor growth inhibition (Figures 6B–D), accompanied by a marked reduction in the number of mitosis and Ki-67 positive cells (Figure 7B). Here, MKI67 is linked to neoplasm.