The demonstrated ability of 7 to upregulate OLIG2 in TGF-β1-stimulated U87 cells (Figure 3F) may, on the one hand, also attest to its anti-GMT potency, as OLIG2 plays an important pro-neural function in the development of the central neural system and is a marker for the proneural glioblastoma subtype (Popova et al., 2014), but on the other hand, the observed, albeit weak, increase in OLIG2 expression under compound 7 treatment may also demonstrate the induction of a compensatory response of glioblastoma cells to the investigated triterpenoid. Here, TGFB1 is linked to glioblastoma.