Regarding CYP3A4 rs35599367-rs2740574 haplotypes, TA haplotype carriers had higher odds for more severe COVID-19 (OR = 6.833; 95% CI = 1.234–37.825: p = 0.028) and for the need for ICU treatment (OR = 10.875; 95% CI = 1.877–62.992: p = 0.008), when compared to CA haplotype. The gene discussed is CYP3A4; the disease is COVID-19.