Izumo sperm-egg fusion 1 (IZUMO1) (log2 fold change = 3.5414; p-value = 0.00012), a sperm adhesion protein, was also found highly abundant in HF bull EVs which aids in sperm—egg fusion by interacting with oocyte-specific GPI-anchored receptor JUNO. The gene discussed is IZUMO1R; the disease is hydrops fetalis.