The epigenetic layer of regulation has been demonstrated in lymphoma cells, were KLF4 is consistently hypermethylated in B lymphocytes sorted from diffuse large-B cell lymphomas (DLBCL), follicular lymphomas (FL) and non Hodgkin lymphoma (NHL) cell lines (Guan et al., 2010; Frazzi et al., 2017; Frazzi et al., 2022). This evidence concerns the gene KLF4 and diffuse large B-cell lymphoma.