KLF4 and non-Hodgkin lymphoma: The epigenetic layer of regulation has been demonstrated in lymphoma cells, were KLF4 is consistently hypermethylated in B lymphocytes sorted from diffuse large-B cell lymphomas (DLBCL), follicular lymphomas (FL) and non Hodgkin lymphoma (NHL) cell lines (Guan et al., 2010; Frazzi et al., 2017; Frazzi et al., 2022).