Histone H3K27 and DNA methylation decrease in BL cells led to the reactivation of the methylation-regulated tumor suppressor genes: Cyclin Dependent Kinase Inhibitor 2B (CDK2NB), KLF4, Inhibitor of DNA Binding 4 (ID4), and Thioredoxin Interacting Protein (TXNIP) (Bialopiotrowicz et al., 2020). The gene discussed is KLF4; the disease is Burkitt lymphoma.