KLF4 and head and neck squamous cell carcinoma: Super-enhancers, defined by size, TF density, association with lineage-specific TFs and activatory histone modifications, were identified in HNSCC and were bound by KLF4 and deltaNp63 (Figure 1E) (Chapuy et al., 2013; Sethi et al., 2017; Tsompana et al., 2020).