Two histopathological types are now retained for craniopharyngiomas (and not two morphological subtypes, as in 2016), justified by distinct clinical, histopathological, and genetic characteristics: “adamantinomatous craniopharyngioma” (associated with a clonal mutation of CTNNB1) (38) and “papillary craniopharyngioma” (with a BRAF mutation) (39). The gene discussed is CTNNB1; the disease is craniopharyngioma.