FLVCR1 and hepatocellular carcinoma: Notably, in the particular case of HCC, analyses of publicly available RNAseq data at the “The Cancer Genome Atlas” (TCGA) showed that: a) FLVCR1 mRNA expression is significantly increased in HCC when compared with normal liver tissue; b) FLVCR1 amplification or mRNA upregulation are observed in 21% of HCC cases; c) FLVCR1 mRNA expression is significantly associated with HCC disease status, histological grade, and vascular invasion; and d) higher expression of FLVCR1 is associated with poor overall survival in HCC (Shen et al., 2018; Tang et al., 2020; Wei et al., 2020).