Conversely, other ISGs, including ISG20, IFI16, APOBEC3G, CXCL10, and CXCL11, which were predominantly expressed in T cells and nMacs, and upregulated during the hepatitis phase, showed a positive correlation with serum ALT levels, indicating their involvement in liver injury (Figure 6E, Figure S9B). Here, IFI16 is linked to hepatitis A virus infection.